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Synthesis of novel, orthogonally protected multifunctional amino acids

✍ Scribed by Siri Ram Chhabra; Anju Mahajan; Weng C. Chan

Book ID
104261692
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
257 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Two synthetic strategies for the generation of differentially protected, chiral tri-amino acids have been developed. The first strategy is based on the reductive amination of a serine-derived oxazolidine aldehyde with mono N-protected ethylenediamine. The second approach involves reductive alkylation of an asparaginederived N-protected diaminopropionate with an N-protected glycinal. The newly generated secondary amine functionality is derivatised to furnish structurally diverse molecules.

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