Synthesis of optically active lipidicα-amino acids and lipidic 2-amino alcohols
✍ Scribed by V. Constantinou-Kokotou; George Kokotos
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 698 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0939-4451
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## Abstract A series of γ‐aminobutyric acid esters of lipidic acids, lipidic peptides and γ‐aminobutyric acid amides of lipidic α‐amino acids and oligomers were synthesised. The GABA conjugates with ester linkages (6j–r) were prepared by coupling the lipidic acids and peptide conjugates to the carb
A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino
## Abstract The α‐amino acids with long alkyl side chains, the so‐called lipidic amino acids 1a–e, and their homo‐oligomers, the lipidic peptides 1p–aj, represent a class of compounds which combine the structural properties of peptides and proteins with the characteristics of lipids and membranes.