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Synthesis of medicinally useful lipidicα-amino acids, 2-amino alcohols and diamines

✍ Scribed by G. Kokotos; V. Martin; V. Constantinou-Kokotou; W. A. Gibbons

Publisher
Springer
Year
1996
Tongue
English
Weight
888 KB
Volume
11
Category
Article
ISSN
0939-4451

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📜 SIMILAR VOLUMES

A general approach to the enantiomeric s
A general approach to the enantiomeric synthesis of lipidic α-amino acids, peptides and vicinal amino alcohols
✍ George Kokotos; JoséM. Padrón; Caterina Noula; William A. Gibbons; Victor S. Mar 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 620 KB

A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino

Lipidic Peptides, XIV. Conversion of Rac
Lipidic Peptides, XIV. Conversion of Racemic Lipidic Amino Acids into Sphingosine and Ceramide Analogues and 1,2-Diamines
✍ Kokotos, George ;Constantinou-Kokotou, Violetta ;Fernandez, Esther Del Olmo ;Tot 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB

## Abstract __N__‐Protected racemic lipidic amino acids 1a–h were converted directly into ceramide analogues 2a–h by chemoselective reduction of their corresponding mixed anhydrides with sodium tetrahydroborate. Conversion of the compounds 1a, b into the corresponding acyl azides, followed by catal

Lipidic peptides, VII. Synthesis and str
Lipidic peptides, VII. Synthesis and structure elucidation of γ-aminobutyric acid conjugates with lipidic acids, lipidic amino acids and lipidic peptides
✍ Hussain, Rohanah ;Toth, Istvan ;Gibbons, William A. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

## Abstract A series of γ‐aminobutyric acid esters of lipidic acids, lipidic peptides and γ‐aminobutyric acid amides of lipidic α‐amino acids and oligomers were synthesised. The GABA conjugates with ester linkages (6j–r) were prepared by coupling the lipidic acids and peptide conjugates to the carb