A general approach to the enantiomeric synthesis of lipidic α-amino acids, peptides and vicinal amino alcohols

✍ Scribed by George Kokotos; JoséM. Padrón; Caterina Noula; William A. Gibbons; Victor S. Martín

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 620 KB
• Volume: 7
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/0957-4166(96)00084-5

✦ Synopsis

A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino alcohols and homo-and hetero-peptides.