Asymmetric halogenation of chiral imide enolates. A general approach to the synthesis of enantiomerically pure α-amino acids.
✍ Scribed by David A Evans; Jon A Ellman; Roberta L Dorow
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 255 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino
A new asymmetric synthesis of disubstituted α-amino acids From the major diastereomers 17c-d the corresponding αamino acids 19c-d are obtained enantiomerically pure upon is presented. This synthesis is based on the chiral 5-methoxy-1,4-oxazin-2-one derivative 5 relying on the α-hydroxy acid hydroly