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Synthesis of novel mimetics of the sialyl Lewis X determinant

✍ Scribed by Alexander Toepfer; Gerhard Kretzschmar; Eckart Bartnik

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
217 KB
Volume
36
Category
Article
ISSN
0040-4039

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The decasaccharide sialyl-trimeric-Lewis x is a component of glycoproteins and glycolipids that serve as E-and P-selectin ligands. The synthesis of this target structure was accomplished by utilizing a combination of chemical and enzymatic methods. Highlights of the chemical synthesis include minima