A novel mimic of the sialyl Lewis x dete
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Nigel M. Allanson; Alan H. Davidson; Fionna M. Martin
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Article
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1993
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Elsevier Science
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French
โ 260 KB
The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils. The interaction of tumour cells and neutrophils with the activated endothelium of blood vessels is the initial event which allows them t