A novel mimic of the sialyl Lewis x determinant

✍ Scribed by Nigel M. Allanson; Alan H. Davidson; Fionna M. Martin

• Publisher: Elsevier Science
• Year: 1993
• Tongue: French
• Weight: 260 KB
• Volume: 34
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)79271-9

✦ Synopsis

The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils. The interaction of tumour cells and neutrophils with the activated endothelium of blood vessels is the initial event which allows them to pass from the circulation into the tissue. The process is mediated by several factors, one of which is the interaction of the lectin domain in E-selectin with its glycosylated ligands on the circulating cellsr. Blockade of this interaction might represent a possible therapy for, (i) reperfusion injury, ARDS and Cmhn's disease in which excessive accumulations of neutmphils are found in the inflamed tissue, (ii) prevention of metastasis of certain types of tumour.