C-Mannose derivatives as potent mimics of sialyl Lewis X
β Scribed by Thomas G. Marron; Thomas J. Woltering; Gabriele Weitz-Schmidt; Chi-Huey Wong
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 215 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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~.bstract--Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex i
The cancer-associated epitope defined by the monoclonal antibody (MAb) 9H8 was shown to be closely related to the T antigen (Thornsen-Friedenreich antigen) by its sensitivity to 0-glycanase treatment of a mucin glycopeptide known to express this epitope. The reactivity with this glycopeptide increas