✦ LIBER ✦

Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-Acetylglucosamine sugar with simple C2-symmetric 1,2-diols

✍ Scribed by Jeremy C. Prodger; Mark J. Bamford; Michael I. Bird; Paul M. Gore; Duncan S. Holmes; Richard Priest; Victoria Saez

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 960 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00055-7

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✦ Synopsis

~.bstract--Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC5o 0.5 mM).