✦ LIBER ✦

Enzymic synthesis of oligosaccharides terminating in the tumor-associated sialyl-Lewis-a determinant

✍ Scribed by Monica M. Palcic; André P. Venot; R.Murray Ratcliffe; Ole Hindsgaul

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 771 KB
Volume: 190
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(89)84141-2

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Chemoenzymatic synthesis of GM3, Lewis x

Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

✍ Mark A. Probert; Mark.J. Milton; Richard Harris; Sergio Schenkman; Jonathan M. B 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 251 KB

In connection with studies on the solution and protein-bound conformation of oligosaecharides, we had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3)

The systematic use of negative nuclear o

The systematic use of negative nuclear overhauser constraints in the determination of oligosaccharide conformations: application to sialyl-Lewis X

✍ Mark R. Wormald; Christopher J. Edge 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 522 KB

ChemInform Abstract: Oligosaccharides Re

ChemInform Abstract: Oligosaccharides Related to Tumor-Associate Antigens. Part 5. Synthesis, Modeling and Binding Affinity of an Ester Analogue of the Terminal Trisaccharide of the Tumor-Associated Antigen Globo-H.

✍ Silvana Canevari; Diego Colombo; Federica Compostella; Luigi Panza; Fiamma Ronch 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

Solid-Phase Synthesis of a Tumor-Associa

Solid-Phase Synthesis of a Tumor-Associated Sialyl-TN Antigen Glycopeptide with a Partial Sequence of the “Tandem Repeat” of the MUC-1 Mucin

✍ Dipl.-Chem. Beate Liebe; Prof. Dr. Horst Kunz 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 489 KB 👁 2 views

Although no evidence of a-haloalkylsamarium formation has been obtained, a reactive cc-iodoethyl species is undoubtedly generated in an optically active form. In conclusion, the reaction of 1,l-diiodoalkanes with samarium(l1) diiodide in the presence of chiral aldehydes produces a-haloaikyl building

Distinct sub-populations of carcinoma-as

Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of breast-cancer patients

✍ Rein Sikut; Ke Zhang; Dan Baeckström; Gunnar C. Hansson 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 856 KB

The cancer-associated epitope defined by the monoclonal antibody (MAb) 9H8 was shown to be closely related to the T antigen (Thornsen-Friedenreich antigen) by its sensitivity to 0-glycanase treatment of a mucin glycopeptide known to express this epitope. The reactivity with this glycopeptide increas

Combined chemical and enzymatic synthesi

Combined chemical and enzymatic synthesis of the sialylated non reducing terminal sequence of GM1b glycolylated ganglioside, a potential human tumor marker

✍ André Lubineau; Claudine Augé; Christine Gautheron-Le Narvor; Jean-Claude Ginet 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 866 KB

Abstrnct--WGlycoly&cossmine 8 was synthesized in 4 steps from anisal glucosamine, via the new crystalline monochloracetyl derivatives 3, 4 and 7. N-Glycolylneuraminic acid 10 was prepared in 59 % yield starting from pyruvate and a mixture of 8 and its manno epimer 9 in a 2:3 ratio, with immobilii si