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Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

✍ Scribed by Mark A. Probert; Mark.J. Milton; Richard Harris; Sergio Schenkman; Jonathan M. Brown; Steven W. Homans; Robert A. Field

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
251 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

In connection with studies on the solution and protein-bound conformation of oligosaecharides, we had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3) from [U-13C]-D-GIc, [U-I 3C] -L-Gal and [U-13C]-pymvate.

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