Starting from Y-lactone intermediates, a novel method for the synthesis of the 5,6-dihydro-4H-cyclopenta[blfuran system has been developed which was utilized to prepare furanoprostacyclin derivatives. Because of the inherent instability of prostacyclin towards hydrolytic conditions 2 and its rapid d
Synthesis of novel aza-prostacyclin analogs
✍ Scribed by Françoise Tubéry; David S. Grierson; H.-P. Husson
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 170 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Structural assignments for the various synthetic intermediates were confirmed by infrared, proton magnetic resonance and mass spectroscopy on chromatographically homogeneous samples. This cycloaddition probably involves the intermediacy of a triazoline rather than a nitrene. See A.L. Logothetis, J
The new aromatic prostacyclin analog 3a and 3b were -synthesized from the allylic alcohol 5 in high regio-and stereoselectivity. Prostacyclin (PGI2, \_ 1) possesses the remarkable biological property of inhibiting the fatal effects caused by thromboxane A2. ' There is, however, an obstacle to the u
Thiazole analogs of prostacyclln were prepared from the cyclopentene (g), itself. obtained z a novel opening of 3,4-epoxycyclopentene with the llthloallylthloether (4). Widespread interest ln the synthesis and biological properties of prostacyclin (PGQ, (1))3 has followed th; discovery that prosta
We describe a new and efficient synthesis of the aza analogs of tacrine based upon the chemistry of the anionically activated trifluoromethyl group. We identify four sites (A-D) which can be successfully altered to afford the desired fused tricyclic heterocycles in high yield (63-82%). The reaction