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A novel and highly efficient synthesis of the aza analogs of tacrine

โœ Scribed by Leon Smith; Alexander S. Kiselyov

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
258 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

We describe a new and efficient synthesis of the aza analogs of tacrine based upon the chemistry of the anionically activated trifluoromethyl group. We identify four sites (A-D) which can be successfully altered to afford the desired fused tricyclic heterocycles in high yield (63-82%). The reaction is believed to proceed through the formation of a quinone methide intermediate.

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