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The synthesis of new aromatic prostacyclin analog

✍ Scribed by Katsuichi Shimoji; Masaki Hayashi

Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
204 KB
Volume
21
Category
Article
ISSN
0040-4039

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✦ Synopsis

The new aromatic prostacyclin analog 3a and 3b were -synthesized from the allylic alcohol 5 in high regio-and stereoselectivity.

Prostacyclin (PGI2, _ 1) possesses the remarkable biological property of inhibiting the fatal effects caused by thromboxane A2. ' There is, however, an obstacle to the use of PGI2 (1) as a therapeutic agent, owing to its instability.1 To achieve tissue selectivity and metabolic stability, several stable PGI2-analogs have been prepared. 2 The 9(O)-methano-PG12 (2) is the most stable analog of those reported, and possesses a potency comparable to the natural PG12

(1).2a

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