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Synthesis of analogs of prostacyclin containing a thiazone ring

✍ Scribed by Robert H. Bradbury; Keith A.M Walker

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 313 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87097-5

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✦ Synopsis

Thiazole analogs of prostacyclln were prepared from the cyclopentene (g), itself. obtained z a novel opening of 3,4-epoxycyclopentene with the llthloallylthloether (4).

Widespread interest ln the synthesis and biological properties of prostacyclin (PGQ,

(1))3 has followed th; discovery that prostacyclln both inhlblts platelet aggregatlon and induces vasodllatlon. However, therapeutic use of prostacyclln 1s precluded by its rapid hydrolysis to 6-oxo-PGFIo, 5 and consequently a wide range of stable analogs of 3 6 prostacyclln has been prepared. '

Of these the only reported "heteroaromatlc"

' Chem. Lett., TW4, 1371.

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