Synthesis of a novel prostacyclin analog containing the bicyclo[3.1.0] hexane ring system. Application of molecular mechanics calculations to organic synthesis

✍ Scribed by S.W. Djuric'; M. Miyano; J.P. Snyder

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 186 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84963-1

✦ Synopsis

The synthesis of a novel prostacyclin analog I has been achieved, incorporating as a key strategic feature a regio-controlled epoxide ring opening (as predicted by MM2 calculations) of a readily available prostaglandin synthon.