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A stereocontrolled synthesis of a novel prostacyclin analog “allene-carbacyclin”. Application of molecular mechanics calculations to organic synthesis.

✍ Scribed by S.W. Djuric; M. Miyano; M. Clare; R.M. Rydzewski

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
201 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of a novel Rrostacyclin/Carbacyclin analog la has been

📜 SIMILAR VOLUMES

Synthesis of a novel prostacyclin analog
Synthesis of a novel prostacyclin analog containing the bicyclo[3.1.0] hexane ring system. Application of molecular mechanics calculations to organic synthesis
✍ S.W. Djuric'; M. Miyano; J.P. Snyder 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 186 KB

The synthesis of a novel prostacyclin analog I has been achieved, incorporating as a key strategic feature a regio-controlled epoxide ring opening (as predicted by MM2 calculations) of a readily available prostaglandin synthon.