## Abstract C^14^‐labelled O,N‐dimethylhydroxyurethane is synthesized from C^14^‐labelled dimethylsulfate and N‐hydroxy‐urethane. It is further converted without purification into O,N‐^14^‐C‐dimethyl‐hydroxylammoniumchloride, which was then nitrosated with sodiumnitrite in acidic medium to give N‐N
Synthesis of N,N-dimethyl[2-14C] morpholinium chloride
✍ Scribed by Jan Adamus; Piotr Paneth; Władysław Reimschűssel
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 163 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
N,N‐dimethyl [2‐^14^C] morpholinium chloride was obtained from [1‐^14^C] acetic acid in five‐step synthesis with [2‐^14^C] morpholine as the intermediate.
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Methyl bromoacetate was reacted with trimethyla~nine-[~'C] dissolved in methanol, forming the methyl ester of [I4C] labeled betaine hydrobromide. The methyl ester was hydrolyzed in an alkaline medium to (carboxymethy1)trimethylammonium hydroxide inner salt, and then transformed into the hydrochlorid
14C N-2-hydroxyethyl-N-nitrosourea was prepared at a specific activity of 30 mCi/mmol and 1 . 2 9 mCi/mmol by a two-step synthetic sequence using 14C ethanolamine as the labelled precursor. Its puri-fication was performed by IiPLC using a Lichrosorb-DIOL column eluted by ethyl ether.The overall radi
## Abstract [2‐^13^C, 2‐^14^C]2‐Aminoethanol hydrochloride was prepared in good yield from Na\*CN in a two step sequence by first converting the Na\*CN to OHCH~2~\*CN and then reducing the nitrile directly with a solution of borane‐tetrahydrofuran complex. The reaction procedure was simple and the
## Abstract Irbesartan (Avapro^™^) is in clinical use as an antihypertensive drug. It is a nonpeptide angiotensin II receptor antagonist. A radiolabeled version of this drug, intended for use in environmental fate studies, was prepared from __N,N__‐dimethyl[^14^C]formamide. Our method of synthesis