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The synthesis of radiolabeled Irbesartan using N,N-dimethyl[14C]formamide as a source of carbon-14 isotope

✍ Scribed by I. Victor Ekhato; Samuel Bonacorsi Jr

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
115 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Irbesartan (Avapro^™^) is in clinical use as an antihypertensive drug. It is a nonpeptide angiotensin II receptor antagonist. A radiolabeled version of this drug, intended for use in environmental fate studies, was prepared from N,N‐dimethyl[^14^C]formamide. Our method of synthesis gave 18% overall yield and a radiochemical purity of 98.22%. Copyright © 2010 John Wiley & Sons, Ltd.

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