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Synthesis of new heterocondensed pteridines

✍ Scribed by A. Z. M. Shaifullah Chowdhury; Yasuyuki Shibata; Masatoshi Morita; Kunimitsu Kaya; Kazuhisa Hiratani

Publisher: Journal of Heterocyclic Chemistry
Year: 2001
Tongue: English
Weight: 54 KB
Volume: 38
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570380522

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✦ Synopsis

Abstract

Reaction of 2‐aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines 3,4 in good yield. Thioxo compound 3a was chlorinated, methylated and subsequently displaced by amines. A simple one‐step synthesis of heterocondensed pteridines 8–13 by reaction of 2‐aminopyrazine with various imino thioacetals was described 8–13.

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