## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Pteridine Synthesis
✍ Scribed by Prof. Dr. W. Pfleiderer; Dipl.-Chem. H.-U. Blank
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 189 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0044-8249
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## Abstract A new synthesis of pteridines possessing a (substituted) (__Z__)‐3‐hydroxyprop‐1‐enyl group at C(6) is based on the acylation of 4‐amino‐5‐nitrosopyrimidines with dienoic acid chlorides, followed by a high‐yielding intramolecular hetero‐__Diels–Alder__ cycloaddition and cleavage of the
## Abstract Reaction of 2‐aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines **3,4** in good yield. Thioxo compound **3a** was chlorinated, methylated and subsequently displaced by amines. A simple one‐step synthesis of heterocondensed pteridines **8–13** by
## Abstract A variety of pyrimidine precursors **12**–**25** were converted into a series of new 7‐hydroxylumazines (=7‐hydroxypteridine‐2,4(1__H__,3__H__)‐diones) **26**–**35** which functioned as starting materials for the transformation into the corresponding 7‐chlorolumazines **36**–**45**. Sub