## Abstract A new synthesis of pteridines possessing a (substituted) (__Z__)‐3‐hydroxyprop‐1‐enyl group at C(6) is based on the acylation of 4‐amino‐5‐nitrosopyrimidines with dienoic acid chlorides, followed by a high‐yielding intramolecular hetero‐__Diels–Alder__ cycloaddition and cleavage of the
A New Synthesis of Pteridines.
✍ Scribed by Ming Xu; Andrea Vasella
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 17 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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📜 SIMILAR VOLUMES
## Abstract Reaction of 2‐aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines **3,4** in good yield. Thioxo compound **3a** was chlorinated, methylated and subsequently displaced by amines. A simple one‐step synthesis of heterocondensed pteridines **8–13** by
## Abstract Pteridines substituted with a 1,1‐, 1,2‐, or 1,1,3‐substituted alkenyl group (mostly (__E__)‐configured) at C(6) were synthesized in high yields by the intramolecular nitroso‐ene reaction of 4‐(alkenoylamino)‐2‐amino‐6‐benzyloxy‐5‐nitroso‐ and 4‐(alkenoylamino)‐2,6‐diamino‐5‐nitrosopyri
## Abstract A variety of pyrimidine precursors **12**–**25** were converted into a series of new 7‐hydroxylumazines (=7‐hydroxypteridine‐2,4(1__H__,3__H__)‐diones) **26**–**35** which functioned as starting materials for the transformation into the corresponding 7‐chlorolumazines **36**–**45**. Sub