𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A New Synthesis of Pteridines

✍ Scribed by Ming Xu; Andrea Vasella

Publisher
John Wiley and Sons
Year
2006
Tongue
German
Weight
86 KB
Volume
89
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new synthesis of pteridines possessing a (substituted) (Z)‐3‐hydroxyprop‐1‐enyl group at C(6) is based on the acylation of 4‐amino‐5‐nitrosopyrimidines with dienoic acid chlorides, followed by a high‐yielding intramolecular hetero‐Diels–Alder cycloaddition and cleavage of the NO bond leading to 4. Thermolysis of the resulting pteridines 4 possessing a benzyloxy group at C(4) led to the products 5, resulting from isomerisation of the 3‐hydroxyprop‐1‐enyl to an 3‐oxopropyl side chain, while the analogous pteridine 8 possessing an NH~2~ group at C(4) remained unaffected.

📜 SIMILAR VOLUMES

A New Synthesis of Pteridines.
A New Synthesis of Pteridines.
✍ Ming Xu; Andrea Vasella 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis of new heterocondensed pteridi
Synthesis of new heterocondensed pteridines
✍ A. Z. M. Shaifullah Chowdhury; Yasuyuki Shibata; Masatoshi Morita; Kunimitsu Kay 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 54 KB

## Abstract Reaction of 2‐aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines **3,4** in good yield. Thioxo compound **3a** was chlorinated, methylated and subsequently displaced by amines. A simple one‐step synthesis of heterocondensed pteridines **8–13** by

A New Synthesis of Pteridines Substitute
A New Synthesis of Pteridines Substituted with Branched and Linear Alkenyl Groups at C(6). The Nitroso-Ene Reaction of 4-(Alkenoylamino)-5-nitrosopyrimidines
✍ Fang-Li Zhang; W. Bernd Schweizer; Ming Xu; Andrea Vasella 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 German ⚖ 321 KB

## Abstract Pteridines substituted with a 1,1‐, 1,2‐, or 1,1,3‐substituted alkenyl group (mostly (__E__)‐configured) at C(6) were synthesized in high yields by the intramolecular nitroso‐ene reaction of 4‐(alkenoylamino)‐2‐amino‐6‐benzyloxy‐5‐nitroso‐ and 4‐(alkenoylamino)‐2,6‐diamino‐5‐nitrosopyri

A New Pteridine Synthesis
A New Pteridine Synthesis
✍ Prof. Dr. W. Pfleiderer; Dipl.-Chem. H.-U. Blank 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB 👁 1 views
Pteridines. Part CXIX. : A New Pteridine
Pteridines. Part CXIX. : A New Pteridine–Purine Transformation
✍ Wolfgang Pfleiderer 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 291 KB

## Abstract A variety of pyrimidine precursors **12**–**25** were converted into a series of new 7‐hydroxylumazines (=7‐hydroxypteridine‐2,4(1__H__,3__H__)‐diones) **26**–**35** which functioned as starting materials for the transformation into the corresponding 7‐chlorolumazines **36**–**45**. Sub