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Synthesis of multiply deuterium-labelled prednisone and prednisolone

✍ Scribed by Hiromi Shibasaki; Takashi Furuta; Yasuji Kasuya

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 332 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290908

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✦ Synopsis

Abstract

We have synthesised prednisone and prednisolone labelled with four deuterium atoms at chemically stable sites ([1,19,19,19‐^2^H~4~]prednisone and [1,19,19,19‐^2^H~4~]prednisolone), starting from [1,1,19,19,19‐^2^H~5~]cortisone. The isotopic purities were demonstrated to be > 98 atom%. There were no indications of deuterium loss from the C‐19 and C‐1 positions during the synthetic sequence involving an oxidation reaction step using selenium dioxide in tert‐butanol.

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