Adinazolam mesylate labeled with stable isotopes was synthesized for conducting bioavailability studies. Adinazolam labeled uniformly with carbon-13, >99% enrichment, in the unsubstituted phenyl ring was prepared for administration as drug. In addition, adinazolam was also dual-labeled with carbon-1
Synthesis of the microbial elicitor syringolide 2 multiply labelled with deuterium
β Scribed by Julian P. Henschke; Rodney W. Rickards
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 646 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2135
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m m R Y we report the synthesis of isotopically pure trideuteriated T-2 toxin, a useful internal standard for mycotoxin analysis. Peracetylation of K F 2 toxin with hewdeuteriated acetic anhydride, follorJed by selective hydrolysis of the C-3 acetate afforded the desired caapound in good yield.
## Abstract Phenylalanines regiospecifically labelled with deuterium in the aromatic ring can be prepared through the hydrogenolysis of tyrosine tetrazolyl ethers using D~2~ gas and a medium pressure catalytic hydrogenator.
## Abstract Five compounds of a group of 2β(arylimino)βimidazolidines, among them Clonidine (St 155), have been labeled with ^14^ in the following manner: Potassium cyanideβ[^14^C] was converted to potassium thiocyanateβ[^14^C] and subsequently to the Nβ²βphenylthiourea using benzoyl chloride and th
Compound \_7 (l',l'-D2-a-T) (see Scheme 3) was synthesized ( 9 ) via a sodium methoxide/CH,OD ring-opening of the methyl ester, 1'7, to give the 4 5.