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Synthesis of adinazolam mesylate multiply labeled with carbon-13 and deuterium

✍ Scribed by Richard S. P. Hsi; Lindsay S. Stelzer

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
399 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

Adinazolam mesylate labeled with stable isotopes was synthesized for conducting bioavailability studies. Adinazolam labeled uniformly with carbon-13, >99% enrichment, in the unsubstituted phenyl ring was prepared for administration as drug. In addition, adinazolam was also dual-labeled with carbon-13, as in the drug, and with deuterium, six atoms per molecule, in the N-methyl groups. The double-labeled material was prepared for use as an internal standard in the mass spectral assay procedure t o be employed in the study.

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