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Synthesis of carbon-14 labeled cilobamine mesylate

✍ Scribed by E. R. Wagner; C. T. Hamilton

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
339 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

14

C i 1 obami ne mesyl ate, Cis-2-( 3,4-di c h l orophenyl -UL C 1 -3 4 ( 1 -methyl e t h y l ) -aminolbicyclo~2.2.2loctan-2-ol methanesul fonate 1, a new antidepressant, was synthesized i n 15% y i e l d from t h e Grignard r e a c t i o n o f l-bromo-3,4-dichlorobenzene-UL C and 3-C( 1 -methylethyl lami no] b i c y c l oC2.2.2loctan-2-one , 5. The bicycloketoamine 5 was prepared i n t h r e e steps from bicycloC2.2.23oct-2-ene.

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