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Synthesis of bisaramil labelled with carbon-14 and deuterium

✍ Scribed by J. Szammer; E. Simon-Trompler; S. Mlinko

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
268 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[6,8‐^14^C~2~]‐Bisaramil: 3‐methyl‐7‐ethyl‐9α‐(4‐chlorobenzoyloxy)‐3,7‐diazabicyclo/3.3.1./nonane‐[6,8‐^14^C~2~] monohydrochloride and [7‐N‐D~5~‐ethyl]‐Bisaramil: 3‐methyl‐7‐[D~5~‐ethyl]‐9α‐(4‐chlorobenzoyloxy)‐3,7‐diazabicyclo/3.3.1./nonane monohydrochloride were synthesized in four steps from ^14^CO~2~ (6% overall yield) and in six steps from [D~6~]‐ethanol (4% overall yield), respectively.

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