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Synthesis of deuterium-labelled etravirine

✍ Scribed by Wei Wang; Wenchao Wu; Zucheng Shen; Liqin Chen

Publisher: John Wiley and Sons
Year: 2011
Tongue: French
Weight: 101 KB
Volume: 54
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1882

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✦ Synopsis

Abstract

This study describes the synthesis of deuterium‐labelled etravirine. Etravirine labelled with six deuteriums was prepared in eight steps starting from phenol with excellent chemical purity and isotopic enrichment. It provides important internal standard for the clinical studies of etravirine. Copyright © 2011 John Wiley & Sons, Ltd.

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