✦ LIBER ✦

Synthesis of deuterium labelled zomepirac

✍ Scribed by Ting-Hui Sun; Frank S. Abbott; Roland Burton; James Orr

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 263 KB
Volume: 19
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580190906

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A simple synthetic procedure has been developed for the preparation of deuterated zomepirac. The deuterium was incorporated into the aromatic ring which is a metabolically stable position.

📜 SIMILAR VOLUMES

Synthesis of tritium labeled zomepirac

✍ David C. Hoerr; Ann T. Scharf; John R. Carson; Larry E. Weaner 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 378 KB 👁 1 views

## Abstract Tritium labeled zomepirac with a specific activity of 85 Ci/mol was prepared by selective alkylation of the penultimate desmethyl precursor using methyl iodide‐^3^H~3~. The alkylation reaction was explored using various bases and solvent media.

Synthesis of deuterium labelled acids

✍ A. J. Kadam; U. V. Desai; R. B. Mane 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB 👁 1 views

Synthesis of deuterium labelled trifluop

Synthesis of deuterium labelled trifluoperazine

✍ H. U. Shetty; E. M. Hawes; K. K. Midha 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB

## Abstract Procedures for the preparation of trifluoperazine with two, four and six deuterium atoms are described. Deuterium was introduced in the propylpiperazine side chain by treatment of the appropriate amide with lithium aluminium deuteride. The isotopic purity of the products was greater tha

Synthesis of deuterium-labelled trantint

Synthesis of deuterium-labelled trantinterol

✍ Hongliang Wen; Li Pan; Yingdan Zhang; Jiacheng Ma; Liqiong Qin; Maosheng Cheng 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

## Abstract Trantinterol, a selective β~2~‐adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium‐labelled trantinterol is described. The labelled trantinterol is used as an internal standard for the analysis and metabol

Synthesis of deuterium-labelled etraviri

Synthesis of deuterium-labelled etravirine

✍ Wei Wang; Wenchao Wu; Zucheng Shen; Liqin Chen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

## Abstract This study describes the synthesis of deuterium‐labelled etravirine. Etravirine labelled with six deuteriums was prepared in eight steps starting from phenol with excellent chemical purity and isotopic enrichment. It provides important internal standard for the clinical studies of etrav

Synthesis of deuterium-labelled viloxazi

Synthesis of deuterium-labelled viloxazine

✍ Kumiko Mamada; Takashi Furuta; Yasuji Kasuya 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 210 KB