𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of labelled [13C6]testosterone and [13C5]19-nortestosterone

✍ Scribed by Cécile Joubert; Chantal Beney; Alain Marsura; Cuong Luu-Duc

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
591 KB
Volume
36
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The condensation of ethyl acetoacetate‐^13^C~4~ and ethyl bromoacetate‐^13^C~2~ afforded, in seven steps, (1,2,3,4,5‐^13^C~5~) 5‐(diethylphosphono)‐2‐pentanone ethylene ketal 9. The reaction of this labelled compound with 7‐[[(1,1‐dimethylethyl)‐dimethylsilyl]oxy]‐1,6,6a,7,8,9,9a, 9b‐octahydro‐6a‐methyl‐[6aS‐(6aa,7a,9aβ,9ba)] cyclopental[f][1]benzopyran‐3 (2H)‐one 13 gave the benzindenone 14 which was converted to (1,2,3,4,10,19‐^13^C~6~)testosterone 17 then, into (1,2,3,4,10‐^13^C~5~) 19‐nortestosterone 18 by a reductive alkylation method.

📜 SIMILAR VOLUMES

Synthesis of [phenyl-13C6]lachnanthocarp
Synthesis of [phenyl-13C6]lachnanthocarpone and other 13C-labelled phenylphenalenones
✍ Felipe Otálvaro; Winston Quiñones; Fernando Echeverri; Bernd Schneider 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB

## Abstract [__phenyl__‐^13^C~6~]Lachnanthocarpone ([__phenyl__‐^13^C~6~]2,6‐dihydroxy‐9‐phenylphenalen‐1‐one), a hypothetical intermediate in the biosynthesis of various natural phenylphenalenones, was prepared in four steps using [U‐^13^C]bromobenzene to introduce the label. Based on related meth

Synthesis of 4-13C and 3,5-13C labeled a
Synthesis of 4-13C and 3,5-13C labeled aniline as precursor of 13C - labeled monosubstituted benzenes
✍ Helmut Rumpel; Hans-Heinrich Limbach 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 167 KB 👁 1 views

Aniline (IV), specifically 13C labeled in the 4-or in the 3,5-position (IVa and IVb), has been synthesized with 55% yield from I3C labeled pnitrophenol (11). The reduction of the NO2 group and the removal of the OH group was performed in one step by reduction and hydrogenolytic cleavage o f p-nitrop

A simple synthesis of 13C6-labelled flav
A simple synthesis of 13C6-labelled flavone and 5-methoxyflavone
✍ Jeffrey J. Ares; Kenneth R. Wehmeyer 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 253 KB

## Abstract The ^13^C~6~‐labelled molecules, flavone and 5‐methoxyflavone, with the carbon‐13 label at all six carbons of the aromatic B ring, have been prepared for use as internal standards in isotope dilution‐mass spectrometry. The key step involves addition of a labelled benzoyl group to the me

Synthesis of 13C-labelled tetramethyltet
Synthesis of 13C-labelled tetramethyltetraselenafulvalene
✍ Jørn B. Christensen; Klaus Bechgaard; Gael Paquignon 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 105 KB 👁 1 views

## Abstract The synthesis of tetramethyltetraselenafulvalene (4,4′,5,5′‐tetramethyl Δ^2,2′^‐bis‐1,3‐diselenole) doubly labelled with carbon‐13 in the 2 and 2′‐positions is described. Copyright © 2001 John Wiley & Sons, Ltd.

Synthesis of 13C-labelled cinnamonitrile
Synthesis of 13C-labelled cinnamonitrile
✍ Elizabeth M. Zippi; Evan Kamperman 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 65 KB 👁 1 views

## Abstract ^13^C‐labelled cinnamonitrile, a compound that possesses both the aromatic functionality of styrene and the nitrile functionality of acrylonitrile has been synthesized in one step using __β__‐bromostyrene and potassium [^13^C]cyanide. The preparation of a target material using ^13^C ‐la