## Abstract The condensation of ethyl acetoacetate‐^13^C~4~ and ethyl bromoacetate‐^13^C~2~ afforded, in seven steps, (1,2,3,4,5‐^13^C~5~) 5‐(diethylphosphono)‐2‐pentanone ethylene ketal 9. The reaction of this labelled compound with 7‐[[(1,1‐dimethylethyl)‐dimethylsilyl]oxy]‐1,6,6a,7,8,9,9a, 9b‐oc
Synthesis of 5-, 6-, 7- and 18-mono-13C-labelled retinals
✍ Scribed by J. M. L. Courtin; G. K.'T Lam; A. J. M. Peters; J. Lugtenburg
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 964 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0165-0513
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## Abstract The ^13^C~6~‐labelled molecules, flavone and 5‐methoxyflavone, with the carbon‐13 label at all six carbons of the aromatic B ring, have been prepared for use as internal standards in isotope dilution‐mass spectrometry. The key step involves addition of a labelled benzoyl group to the me
## Abstract (12,13‐^13^C~2~)Retinal, (13,14‐^13^C~2~)retinal, (19‐^13^C)retinal and (20‐^13^C)retinal (1) were prepared in a simple fashion in high yield via a consecutive strategy. The key step is the reaction of a __N__‐methoxy‐__N__‐methylamide with an alkyllithium or a Grignard reagent. The pre
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