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A simple synthesis of 13C6-labelled flavone and 5-methoxyflavone

✍ Scribed by Jeffrey J. Ares; Kenneth R. Wehmeyer

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
253 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The ^13^C~6~‐labelled molecules, flavone and 5‐methoxyflavone, with the carbon‐13 label at all six carbons of the aromatic B ring, have been prepared for use as internal standards in isotope dilution‐mass spectrometry. The key step involves addition of a labelled benzoyl group to the methyl group of a hydroxyacetophenone, forming a 1,3‐diketone. Overall yields from ^13^C~6~‐benzoic acid were 38% for the labelled flavone and 45% for the labelled 5‐methoxyflavone.

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