β Scribed by Fred S. Fry Jr.; Millard Maienthal; Walter R. Benson
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A new synthesis of thiphenamil hydrochloride, 2-(diethy1aminoethyl)diphenylthioacetate hydrochloride, a direct-acting smooth muscle antispasmodic with no appreciable anticholinergic or muscarinic activity, is described. The synthesis is carried out under mild conditions and is much simpler than any
hydrochloride, a novel beta-adrenergic antagonist, was synthesized in our laboratory for metabolic studies. ride from 2-hydroxybenzonitrile-[ ~y a n o -~~C ] utilizing 13C-copper(I) cyanide as an isotopic starting material is described.
## Abstract The synthesis of [^15^N]β labelled procaine hydrochloride, using (^15^NH~4~)~2~SO~4~ as starting isotopically labelled material, is presented. The experimental procedure is an adaptation of the synthesis methods for the corresponding unlabelled compounds.
## Abstract Ractopamine HCl was uniformly labeled with carbonβ14 in one of two phenyl rings as a requirement for animal metabolism studies. The sixβstep synthesis was completed in a 14% yield. Product instability on silica gel complicated purification, but development of a chromatographic method af