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New synthesis of thiphenamil hydrochloride

✍ Scribed by A. Garnett Richardson

Publisher: John Wiley and Sons
Year: 1966
Tongue: English
Weight: 95 KB
Volume: 55
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600551133

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✦ Synopsis

A new synthesis of thiphenamil hydrochloride, 2-(diethy1aminoethyl)diphenylthioacetate hydrochloride, a direct-acting smooth muscle antispasmodic with no appreciable anticholinergic or muscarinic activity, is described. The synthesis is carried out under mild conditions and is much simpler than any other known method of preparing this drug.

IIIPHENAMIL HYDROCHLORIDE [Z-( diethylaniino-T ethy1)diphenylthioacetatc hydrochloridc] was

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