Synthesis of Highly Methylated Indole-3-acetic Acids.
β Scribed by Payne, C. A.; Stevens, F. J.
- Book ID
- 126993788
- Publisher
- American Chemical Society
- Year
- 1965
- Tongue
- English
- Weight
- 209 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0021-9568
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π SIMILAR VOLUMES
## Abstract A general method for microscale synthesis of ^14^Cβlabeled indoleβ3βacetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]β2βoxoglutarate to generate the halogenated indoleβ3βacetic acid. 3β
3-Methyleneoxindole is a cytotoxic metabolite of indole-3-acetic acid with potential for use in cancer therapy. This species and ring-substituted analogues are conveniently synthesised from the corresponding isatins via a Peterson olefination.