## Abstract A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐
Synthesis and antiviral activity of functionally substituted indole-3-acetic acids
✍ Scribed by A. V. Ivashchenko; P. M. Yamanushkin; O. D. Mit’kin; I. A. Leneva; I. T. Fedyakina
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 103 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0091-150X
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## Abstract For Abstract see ChemInform Abstract in Full Text.
3-Methyleneoxindole is a cytotoxic metabolite of indole-3-acetic acid with potential for use in cancer therapy. This species and ring-substituted analogues are conveniently synthesised from the corresponding isatins via a Peterson olefination.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An efficient and expedient synthetic route to 2-acylindole-3-acetic acids is described. This work first demonstrates a one-pot room-temperature indole ring construction via the in situ generation of indoline intermediate.