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A convenient synthesis of 3-methyleneoxindoles: cytotoxic metabolites of indole-3-acetic acids

✍ Scribed by Sharon Rossiter

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
61 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

3-Methyleneoxindole is a cytotoxic metabolite of indole-3-acetic acid with potential for use in cancer therapy. This species and ring-substituted analogues are conveniently synthesised from the corresponding isatins via a Peterson olefination.

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## Abstract A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐