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Synthesis and cytotoxic activity of latentiated derivatives of 3-methyleneoxindole

โœ Scribed by M. J. Kornet; A. P. Thio; J. H. Thorstenson


Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
359 KB
Volume
66
Category
Article
ISSN
0022-3549

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A convenient synthesis of 3-methyleneoxi
โœ Sharon Rossiter ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 61 KB

3-Methyleneoxindole is a cytotoxic metabolite of indole-3-acetic acid with potential for use in cancer therapy. This species and ring-substituted analogues are conveniently synthesised from the corresponding isatins via a Peterson olefination.