An easy access to the 3-fluoroazetidinone 4a based on electrophilic fluorination, is reported. The fluorination of the ~l-lactam 7 with Differding's N-fluorosulfonimide proceeds stereoselectively, under mild conditions and in good yield.
Synthesis of fluorinated azetidinones
β Scribed by Roger Joyeau; Huguette Molines; Michel Wakselman
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 22 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-1139
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