A short chemical process is described for the synthesis of optically active 3y roxy-4-alkoxycarbonyl-Z-azetidinones (R-lactams) from L-tartaric acid. Tartaric acid is an extremely useful and versatile member of the chiral pool. Since nearly any type of f+hydroxy acid can be converted to a 8-lactam (
Synthesis of 4-substituted 2-azetidinones
โ Scribed by Duy H. Hua; Akhilkumar Verma
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 177 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Indium-Mediated Substitution of 4-Acetoxy-2-azetidinones: Synthesis of 4-Allyl-2-azetidinones. -Allylation of 4-acetoxy-2-azetidinones (I) is afforded under mild conditions in good yields using indium and alkyl bromides in the presence of potassium iodide.The products are interesting synthons for t
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Ketene generated from acetyl chloride or chloroacetyl chloride adds on indolyl Schiff's base double bond to afford 1โbutylโ3โsubstitutedโ4โ(2โarylโ1__H__โindolโ3โyl)โ2โazetidinones in THF. The reaction proceeds stereospecifically via concerted __trans__ [2+2] cycloaddition. The synthesi
The diastereoselectivity of the intermolecular Diels-Alder reaction of 2-azetidinone-tethered dienes was investigated. Diene precursors were prepared from 4-azetidinone-2-carbaldehydes through an allylation-dehydration process or by the sequence Wittig reaction/enolate trapping. Dienes with a ฮฒlacta