✦ LIBER ✦

Synthesis, spectral, and antimicrobial studies of 1-butyl-3-substituted-4-(2-aryl-1H-indol-3-yl)-2-azetidinones

✍ Scribed by Vijai N. Pathak; Ragini Gupta; Meenu Garg

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 120 KB
Volume: 15
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20052

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✦ Synopsis

Abstract

Ketene generated from acetyl chloride or chloroacetyl chloride adds on indolyl Schiff's base double bond to afford 1‐butyl‐3‐substituted‐4‐(2‐aryl‐1__H__‐indol‐3‐yl)‐2‐azetidinones in THF. The reaction proceeds stereospecifically via concerted trans [2+2] cycloaddition. The synthesized compounds have been characterized by elemental analyses and spectral data (IR, PMR, and mass). All synthesized compounds have been evaluated for antibacterial and antifungal activities, and 4g to 4l have shown promising results. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:494–501, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20052

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