An easy access to the 3-fluoroazetidinone 4a based on electrophilic fluorination, is reported. The fluorination of the ~l-lactam 7 with Differding's N-fluorosulfonimide proceeds stereoselectively, under mild conditions and in good yield.
The stereoselective synthesis of 3-fluoro-azetidinones
β Scribed by Koichi Araki; John A. Wichtowski; John T. Welch
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 271 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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