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Synthesis of epibatidine isomers: endo-5- and 6- (6′-chloro-3′-pyridyl-2-azabicyclo[2.2.1]heptanes

✍ Scribed by Cox, Caroline D.; Malpass, John R.; Gordon, John; Rosen, Alan


Book ID
121431766
Publisher
Royal Society of Chemistry
Year
2001
Weight
193 KB
Volume
19
Category
Article
ISSN
1472-7781

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Synthesis of 5- and 6- chloropyridyl-sub
✍ John R. Malpass; Caroline D. Cox 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 226 KB

A synthetic route to the epibatidine analogue endo-5-(6-chloro-3-pyridyl)-2-azabicyclo[2.2.1]heptane and the corresponding endo-6-isomer is described, starting from a readily-available 2-azabicyclo[2.2.1]hept-5-ene derivative. Both the exo-5-and exo-6-compounds are also shown to be accessible from t