ChemInform Abstract: Synthesis of 5- and 6-(6-Chloro-3-pyridyl)-2-azabicyclo[2.2.0]hexanes. Epibatidine Analogues.
โ Scribed by Grant R. Krow; Jing Yuan; Qiuli Huang; Michael D. Meyer; David J. Anderson; Jeffrey E. Campbell; Patrick J. Carroll
- Publisher
- John Wiley and Sons
- Year
- 2001
- Weight
- 31 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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An Epoxide Rearrangement -Radical Rearrangement Approach to 6-Substituted 2-Azabicyclo[2.2.1]-5-heptenes: Synthesis of an Epibatidine Analogue. -Base-promoted isomerization of the epoxide (I) provides the azanortricyclanol (II). The latter can be readily converted to the derivatives (V) as precurso
## Novel Conversion of Perfluoro(2,6-dimethyl-1-azacyclohexene) to 3,3,4,4,5-Pentafluoro-2,6-diphenyl-2,6-bis (trifluoromethyl)-1azabicyclo[3.1.0]hexane. -Treatment of perfluoro-azacyclohexene (I) with 2 equiv. of phenyllithium (V) in a cyclohexane/Et 2 O mixture provides access to azabicyclohex