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Synthesis of dinucleoside and dinucleotide phosphorodithioates via a phosphotriester approach

✍ Scribed by Eric K. Yau; Yun-Xi Ma; M.H. Caruthers

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
316 KB
Volume
31
Category
Article
ISSN
0040-4039

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Solid phase synthesis of oligoribonucleo
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphotriester approach
✍ Toshiki Tanaka; Masaya Orita; Seiichi Uesugi; Morio Ikehara πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 510 KB

Oligoribonucleotides with chain length of 6-9 were synthesized on a polystyrene support using o-nitrobenzyl protection of 2'-hydroxyls via phosphotiriester method. The condensation reactions between N-acvl-5 and nucleoside bound to the resin using l-mesitylenesulfonyl-3-nitro-1H-1,2,4-triazole (MS