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Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Approach

✍ Scribed by Takeshi Wada; Mamoru Shimizu; Natsuhisa Oka; Kazuhiko Saigo


Publisher
John Wiley and Sons
Year
2004
Weight
59 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract A gram scale enzymatic synthesis of eight, dinucleoside monophosphates (ApC, ApU, CpC, CpU, GpC, GpU, UpC, and UpU) is described. The synthesis involves a reaction between the appropriate ribonucleoside‐2β€²,3′‐cyclie phosphates and cytidine or uridine in the presence of ribonuelease from