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Synthesis of deuterium labelled eumelanin (precursor) metabolites

✍ Scribed by Stanislav Pavel; Frits A. J. Muskiet

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
335 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Starting from 2,5,6-trideuter0-3,4-dihydroxyphenylethylamine, a mixture of 4,7-dideutero-5,6-dihydroxyindole, 4,7-dideutero-5-hydroxy--6-trideuteromethoxyindole and 4,7-dideutero-6-hydroxy-5-trideuteromethoxyindole was prepared. A similar procedure for the preparation of 4,7--dideutero-5,6-dihydroxyindolyl-2-carboxylic, 4,7-dideutero-5-hydroxy-6--trideuteromethoxyindolyl-2-carboxylic and 4,7-dideutero-6-hydroxy-5--trideuteromethoxyindolyl-2-carboxylic acids from methyl ester of 2,5,6trideutero-L-3,4-dihydroxyphenylalanine is described. The procedures are designed for the production of deuterium labelled internal standards for mass fragmentographic analysis of eumelanin (precursor) metabolites in urine. The methods can also be used for the synthesis of non-deuterated ana 1 og s .

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