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Synthesis of deuterium-labelled paclitaxel and its hydroxyl metabolite

✍ Scribed by Lei Tian; Keying Wu; Jie Tao; Liqin Chen

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
216 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

This paper describes the synthesis of deuterium‐labelled paclitaxel and its hydroxyl metabolite. Paclitaxel labelled with ^2^H was obtained in four steps using the commercially available [^2^H~5~]benzoic chloride as the stable labelled reagent with a 40% overall yield. The hydroxyl metabolite labelled with ^2^H was prepared starting from deuterium‐labelled paclitaxel in six steps with a 42% overall yield based on unrecovered starting material. Copyright © 2011 John Wiley & Sons, Ltd.

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